Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy

Shunhao Wang; Lu Shang; Linlin Li; Yingjie Yu; Chongwei Chi; Kun Wang; Jie Zhang; Run Shi; Heyun Shen; Geoffrey I N Waterhouse; Sijin Liu; Jie Tian; Tierui Zhang; Huiyu Liu

doi:10.1002/adma.201602197

Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy

Adv Mater. 2016 Oct;28(38):8379-8387. doi: 10.1002/adma.201602197. Epub 2016 Jul 27.

Authors

Shunhao Wang^{1

2

3

4}, Lu Shang², Linlin Li⁵, Yingjie Yu⁶, Chongwei Chi⁷, Kun Wang⁷, Jie Zhang^{3

4}, Run Shi^{2

4}, Heyun Shen¹, Geoffrey I N Waterhouse⁸, Sijin Liu⁹, Jie Tian⁷, Tierui Zhang¹⁰, Huiyu Liu¹¹

Affiliations

¹ Beijing Key Laboratory of Bioprocess, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
² Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
³ State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China.
⁴ University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
⁵ Beijing Institute of Nanoenergy and Nanosystems, National Center for Nanoscience and Technology (NCNST), Chinese Academy of Sciences, Beijing, 100083, P. R. China.
⁶ Department of Materials Science and Engineering, State University of New York at Stony Brook, Stony Brook, NY, 11790, USA.
⁷ Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
⁸ School of Chemical Sciences, The University of Auckland, Auckland, 1142, New Zealand.
⁹ State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China. sjliu@rcees.ac.cn.
¹⁰ Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China. tierui@mail.ipc.ac.cn.
¹¹ Beijing Key Laboratory of Bioprocess, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. liuhy@mail.buct.edu.cn.

PMID: 27461987
DOI: 10.1002/adma.201602197

Abstract

Mesoporous carbon nanospheres containing porphyrin-like metal centers (denoted as "PMCS") are successfully synthesized by the pyrolysis of an imidazolate framework using a mesoporous-silica protection strategy. The PMCS allow infrared and photoacoustic imaging and synergetic photothermal therapy/photodynamic therapy derived from the porphyrin-like moieties, offering the possibility of real-time monitoring of therapeutic processes and image-guided precise conformal phototherapy. PMCS thus represent a novel multifunctional theranostic platform for improved treatment efficiencies.

Keywords: mesoporous carbon nanoframes; photodynamic therapy; photothermal therapy; porphyrin-like metal centers; reactive oxygen species.

MeSH terms

Carbon
Metals
Nanospheres*
Phototherapy
Porphyrins

Substances

Metals
Porphyrins
Carbon