Unusual Association of Hairy Cell Leukemia and Monoclonal Large Granular Lymphocyte Proliferation

F Dazzi; E D'andrea; A Veronesi; M Chilosi; D Sgarabotto; A Girolami

doi:10.3109/10428199009069298

Unusual Association of Hairy Cell Leukemia and Monoclonal Large Granular Lymphocyte Proliferation

Leuk Lymphoma. 1990;2(6):433-6. doi: 10.3109/10428199009069298.

Authors

F Dazzi¹, E D'andrea², A Veronesi¹, M Chilosi³, D Sgarabotto¹, A Girolami¹

Affiliations

¹ a Second Department of Medicine, Institute of Semeiotics, Interuniversity Center for Cancer Research (CIRC), University of Padua, Italy.
² b Second Department of Medicine, Institute of Oncology, Interuniversity Center for Cancer Research (CIRC), University of Padua, Italy.
³ c Institute of Pathology, University of Verona, Italy.

PMID: 27457049
DOI: 10.3109/10428199009069298

Abstract

The exceptional association of Hairy cell leukemia (HCL) and monoclonal large granular lymphocyte (LGL) proliferation is reported in the same patient. Immunophenotypic analysis, showed that most of the PBMC expressed CD3 and HNK-1 molecules, while in the bone marrow biopsy an infiltration by CD22 +/CD25 + lymphoid cells was detectable. The monoclonal rearrangement of βTTCR genes in the PBMC, suggests that the increased LGL is not reactive. Nevertheless, a possible interaction between the two entities is proposed. The high sIL-2R serum levels, related to proliferation of hairy cells, might account for the lack of NK activity observed in the LGL.

Keywords: Hairy cell leukemia; large granular lymphocyte proliferation; soluble IL-2R.