Fast detection of homogeneous chemiluminescent immunoassays with a sensitive photoplate

J Chromatogr. 1989 Apr 7;489(1):245-53. doi: 10.1016/s0378-4347(00)82902-3.

Abstract

Chemiluminescent immunoassays performed in microtitre plates can be detected with a sensitive instant photoplate. An apparatus was constructed for this purpose making use of whole polystyrene microtitre plates plates possible. One of the advantages of immunoassays using enzyme-enhanced chemiluminescence is the possibility for developing homogeneous immunoassays. An example is described for a solid-phase immunoassay for 17 beta-testosterone making use of non-specific energy transfer in combination with photoplate detection. A testosterone-peroxidase conjugate was used as label. Quantification was performed using image-analysis techniques. The assay was also performed with colorimetric substrates for comparison.

MeSH terms

  • Immunoassay / methods*
  • Luminescent Measurements
  • Testosterone / analysis

Substances

  • Testosterone