AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases

L Emdad; S K Das; B Hu; T Kegelman; D-C Kang; S-G Lee; D Sarkar; P B Fisher

doi:10.1016/bs.acr.2016.05.002

AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases

Adv Cancer Res. 2016:131:97-132. doi: 10.1016/bs.acr.2016.05.002. Epub 2016 Jun 17.

Authors

L Emdad¹, S K Das², B Hu³, T Kegelman³, D-C Kang⁴, S-G Lee⁵, D Sarkar², P B Fisher⁶

Affiliations

¹ Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States. Electronic address: luni.emdad@vcuhealth.org.
² Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.
³ Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.
⁴ Ilsong Institute of Life Science, Hallym University, Anyang, Republic of Korea.
⁵ Cancer Preventive Material Development Research Center, Institute of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
⁶ Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States. Electronic address: paul.fisher@vcuhealth.org.

PMID: 27451125
DOI: 10.1016/bs.acr.2016.05.002

Abstract

Since its original discovery in 2002, AEG-1/MTDH/LYRIC has emerged as a primary regulator of several diseases including cancer, inflammatory diseases, and neurodegenerative diseases. AEG-1/MTDH/LYRIC has emerged as a key contributory molecule in almost every aspect of cancer progression, including uncontrolled cell growth, evasion of apoptosis, increased cell migration and invasion, angiogenesis, chemoresistance, and metastasis. Additionally, recent studies highlight a seminal role of AEG-1/MTDH/LYRIC in neurodegenerative diseases and obesity. By interacting with multiple protein partners, AEG-1/MTDH/LYRIC plays multifaceted roles in the pathogenesis of a wide variety of diseases. This review discusses the current state of understanding of AEG-1/MTDH/LYRIC regulation and function in cancer and other diseases with a focus on its association/interaction with several pivotal protein partners.

Keywords: AEG-1/MTDH/LYRIC; CNS diseases; Cancer aggressiveness; Interacting proteins; Obesity.

Publication types

Review

MeSH terms

Cell Adhesion Molecules / metabolism*
Central Nervous System Diseases / physiopathology*
Gene Expression Regulation, Neoplastic*
Humans
Membrane Proteins
Neoplasms / physiopathology*
Obesity / physiopathology*
RNA-Binding Proteins

Substances

Cell Adhesion Molecules
MTDH protein, human
Membrane Proteins
RNA-Binding Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding