1 Department of Critical Care, University of Edinburgh, Royal Infirmary Edinburgh, Edinburgh, Midlothian, United Kingdom; Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom; Department of Critical Care, University of Edinburgh, Edinburgh, Scotland, United Kingdom; Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh Department of Critical Care, University of Edinburgh, Edinburgh, Scotland, United Kingdom.