Prader Willi Syndrome: Genetics, Metabolomics, Hormonal Function, and New Approaches to Therapy

Adv Pediatr. 2016 Aug;63(1):47-77. doi: 10.1016/j.yapd.2016.04.005.

Authors

Krystal A Irizarry¹, Mark Miller¹, Michael Freemark¹, Andrea M Haqq²

Affiliations

¹ Division of Pediatric Endocrinology, Duke University Medical Center, 3000 Erwin Road, Suite 200, Durham, NC 27705, USA.
² Division of Pediatric Endocrinology, University of Alberta, 1C4 Walter C. Mackenzie Health Sciences Center, 8440 - 112 Street Northwest, Edmonton, Alberta T6G 2R7, Canada. Electronic address: haqq@ualberta.ca.

No abstract available

Keywords: Childhood obesity syndrome; Growth hormone; Hyperphagia; Imprinting defect.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adrenal Insufficiency / diagnosis
Adrenal Insufficiency / etiology
Bariatric Surgery
Body Composition
Child
Child Behavior Disorders / etiology
Diabetes Mellitus, Type 2 / etiology
Diet, Reducing
Dwarfism / etiology
Energy Metabolism
Ghrelin / blood
Gonadal Steroid Hormones / deficiency
Hormone Replacement Therapy
Human Growth Hormone / deficiency
Human Growth Hormone / therapeutic use
Humans
Hyperphagia / etiology
Hypogonadism / etiology
Hypothyroidism / etiology
Mental Disorders / etiology
Obesity / complications
Prader-Willi Syndrome / complications*
Prader-Willi Syndrome / diagnosis
Prader-Willi Syndrome / genetics
Prader-Willi Syndrome / therapy*
Sleep Wake Disorders / etiology

Substances

Ghrelin
Gonadal Steroid Hormones
Human Growth Hormone

Grants and funding