Overexpression of sirtuin 6 suppresses allergic airway inflammation through deacetylation of GATA3

J Allergy Clin Immunol. 2016 Nov;138(5):1452-1455.e13. doi: 10.1016/j.jaci.2016.05.019. Epub 2016 Jun 11.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Animals
  • Asthma / metabolism
  • GATA3 Transcription Factor / metabolism*
  • Hypersensitivity / metabolism*
  • Inflammation / metabolism*
  • Lung / drug effects
  • Lung / metabolism
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Ovalbumin / physiology
  • Sirtuins / metabolism*
  • Th2 Cells / drug effects
  • Th2 Cells / metabolism

Substances

  • GATA3 Transcription Factor
  • Gata3 protein, mouse
  • Ovalbumin
  • Sirt6 protein, mouse
  • Sirtuins