Docetaxel for Metastatic Hormone-sensitive Prostate Cancer: Urgent Need to Minimize the Risk of Neutropenic Fever

Eur Urol. 2016 Nov;70(5):707-708. doi: 10.1016/j.eururo.2016.06.041. Epub 2016 Jul 12.

Abstract

First-line docetaxel treatment for metastatic castration-sensitive prostate cancer is associated with higher rates of neutropenic fever compared with those with castration-resistant disease, and prophylactic granulocyte colony-stimulating factor should be considered in those harboring risk factors for developing neutropenia.

Publication types

  • Editorial

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Chemotherapy-Induced Febrile Neutropenia* / diagnosis
  • Chemotherapy-Induced Febrile Neutropenia* / etiology
  • Chemotherapy-Induced Febrile Neutropenia* / prevention & control
  • Docetaxel
  • Humans
  • Male
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Prostatic Neoplasms* / drug therapy
  • Prostatic Neoplasms* / pathology
  • Prostatic Neoplasms, Castration-Resistant* / drug therapy
  • Prostatic Neoplasms, Castration-Resistant* / pathology
  • Randomized Controlled Trials as Topic
  • Taxoids* / administration & dosage
  • Taxoids* / adverse effects

Substances

  • Antineoplastic Agents
  • Taxoids
  • Docetaxel