A case of TAFRO syndrome, a variant of multicentric Castleman's disease, successfully treated with corticosteroid and cyclosporine A

Mod Rheumatol. 2019 Jan;29(1):198-202. doi: 10.1080/14397595.2016.1206243. Epub 2016 Jul 14.

Abstract

We report a case of a 46-year-old woman with fever, pleural effusion, massive ascites, severe edema, hepatosplenomegaly, elevation of serum creatinine level, proteinuria, and severe thrombocytopenia. Her clinical features were compatible with TAFRO syndrome proposed as a variant of multicentric Castleman's disease, that is occasionally associated with poor prognosis. Treatment with corticosteroid improved her symptoms partially. However, thrombocytopenia, ascites, and edema persisted. The use of cyclosporine A successfully improved her condition, resulting in remission.

Keywords: Corticosteroid; Cyclosporine A; Multicentric Castleman’s disease; TAFRO syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / therapeutic use*
  • Castleman Disease / diagnosis
  • Castleman Disease / drug therapy*
  • Cyclosporine / administration & dosage
  • Cyclosporine / therapeutic use*
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / therapeutic use*
  • Middle Aged

Substances

  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Cyclosporine

Supplementary concepts

  • Multi-centric Castleman's Disease