Abstract
Chemical investigation on the cultures of the fungus Psilocybe merdaria resulted in the first isolation of 10 compounds including two new ones 11,14-dihydroxylneoechinulin E (1) and (S)-4-(4-methylpent-3-en-1-yl)-butyrolactone (2). Their structures were elucidated from the analysis of 1D and 2D NMR and MS data. Among them, compound 7 showed inhibitory activity against AChE with 20% percentage at a concentration of 50 μg/ml.
Keywords:
AChE inhibitory activity; Psilocybe; Psilocybe merdaria; indole alkaloids.
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemistry
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology
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Acetylcholinesterase / drug effects
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China
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology
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Fungi / metabolism
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Indole Alkaloids / chemistry*
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology
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Inhibitory Concentration 50
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Molecular Structure
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Psilocybe / chemistry*
Substances
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(S)-4-(4-methylpent-3-en-1-yl)-butyrolactone
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11,14-dihydroxylneoechinulin E
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Cholinesterase Inhibitors
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Indole Alkaloids
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Acetylcholinesterase
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4-Butyrolactone