Metabolic RemodeLIN of Pluripotency

Julie Mathieu; Hannele Ruohola-Baker

doi:10.1016/j.stem.2016.06.016

Metabolic RemodeLIN of Pluripotency

Cell Stem Cell. 2016 Jul 7;19(1):3-4. doi: 10.1016/j.stem.2016.06.016.

Authors

Julie Mathieu¹, Hannele Ruohola-Baker²

Affiliations

¹ Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
² Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address: hannele@uw.edu.

PMID: 27392218
DOI: 10.1016/j.stem.2016.06.016

Abstract

Cellular metabolism is a key regulator of cell fate, including fate in pluripotent stem cells. Now in Cell Stem Cell, Zhang et al. (2016) show that Lin28 controls the metabolic transition from naive to primed pluripotency by directly repressing oxidative metabolism genes and metabolic intermediates involved in epigenetic regulation independently of let-7.

Publication types

Comment

MeSH terms

Cell Differentiation / genetics
Epigenesis, Genetic*
Pluripotent Stem Cells*