Effect of Hepatitis C Virus Coinfection on the Content of CD4(+) and CD8(+) T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy

L B Korolevskaya; K V Shmagel; E V Saidakova; N G Shmagel; S V Slobodchikova; V A Chereshnev

doi:10.1007/s10517-016-3395-1

Effect of Hepatitis C Virus Coinfection on the Content of CD4(+) and CD8(+) T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy

Bull Exp Biol Med. 2016 Jun;161(2):281-3. doi: 10.1007/s10517-016-3395-1. Epub 2016 Jul 7.

Authors

L B Korolevskaya^{1

2}, K V Shmagel^{3

4}, E V Saidakova^{3

4}, N G Shmagel^{3

5}, S V Slobodchikova^{3

4}, V A Chereshnev^{3

6

7}

Affiliations

¹ Perm State National Research University, Perm, Russia. bioqueen@mail.ru.
² Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia. bioqueen@mail.ru.
³ Perm State National Research University, Perm, Russia.
⁴ Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
⁵ Perm Regional Center for Prevention of AIDS and Infectious Diseases, Perm, Russia.
⁶ Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
⁷ Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg, Russia.

PMID: 27388630
DOI: 10.1007/s10517-016-3395-1

Abstract

We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4(+) T cells and an increase in the count of central CD8(+) memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4(+) memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.

Keywords: HCV coinfection; HIV infection; T cell subpopulations; antiretroviral therapy.

MeSH terms

Adult
Anti-HIV Agents / pharmacology
Anti-HIV Agents / therapeutic use*
CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / virology
CD8-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / virology
Case-Control Studies
Coinfection / drug therapy
Coinfection / immunology
Coinfection / virology
Female
HIV Infections / drug therapy
HIV Infections / immunology*
HIV Infections / virology
Hepatitis C, Chronic / drug therapy
Hepatitis C, Chronic / immunology*
Hepatitis C, Chronic / virology
Humans
Interferons / pharmacology
Interferons / therapeutic use*
Male
Thymus Gland / immunology
Thymus Gland / pathology

Substances

Anti-HIV Agents
Interferons