Functional Photoacoustic Imaging of Gastric Acid Secretion Using pH-Responsive Polyaniline Nanoprobes

Junwei Li; Hong Xiao; Soon Joon Yoon; Chengbo Liu; Drew Matsuura; Wanyi Tai; Liang Song; Matthew O'Donnell; Du Cheng; Xiaohu Gao

doi:10.1002/smll.201601359

Functional Photoacoustic Imaging of Gastric Acid Secretion Using pH-Responsive Polyaniline Nanoprobes

Small. 2016 Sep;12(34):4690-6. doi: 10.1002/smll.201601359. Epub 2016 Jun 30.

Authors

Junwei Li¹, Hong Xiao², Soon Joon Yoon¹, Chengbo Liu³, Drew Matsuura¹, Wanyi Tai¹, Liang Song⁴, Matthew O'Donnell⁵, Du Cheng⁶, Xiaohu Gao⁷

Affiliations

¹ Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
² PCFM Lab of Ministry of Education School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, China.
³ Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
⁴ Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. liang.song@siat.ac.cn.
⁵ Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA. odonnel@uw.edu.
⁶ PCFM Lab of Ministry of Education School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, China. chengdu@mail.sysu.edu.cn.
⁷ Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA. xgao@uw.edu.

Abstract

A stomach functional imaging technique based on photoacoustics achieves noninvasive gastric acid secretory assessment utilizing pH-responsive polyaniline nanoprobes. A testing protocol mimicking clinical practice is established using a mouse model. After imaging, the nanoprobes are excreted outside the body without inducing systematic toxicity. Further optimization and translation of this technology can help alleviate patients' suffering and side effects.

Keywords: gastric acid secretory assessment; nanoparticles; nanoprobes; photoacoustic imaging; polyaniline; stomach imaging.

MeSH terms

Administration, Oral
Aniline Compounds / chemistry*
Animals
Cell Death / drug effects
Cell Line, Tumor
Female
Gastric Acid / metabolism*
Humans
Hydrogen-Ion Concentration
Imaging, Three-Dimensional*
Magnetite Nanoparticles / administration & dosage
Magnetite Nanoparticles / chemistry*
Magnetite Nanoparticles / toxicity
Mice
Mice, Inbred BALB C
Mice, Nude
Photoacoustic Techniques / methods*

Substances

Aniline Compounds
Magnetite Nanoparticles
polyaniline

Abstract

MeSH terms

Substances

Grants and funding