DNA Damage and Aging Around the Clock

Paula Gutierrez-Martinez; Derrick J Rossi; Isabel Beerman

doi:10.1016/j.molmed.2016.06.006

DNA Damage and Aging Around the Clock

Trends Mol Med. 2016 Aug;22(8):635-637. doi: 10.1016/j.molmed.2016.06.006. Epub 2016 Jun 23.

Authors

Paula Gutierrez-Martinez¹, Derrick J Rossi², Isabel Beerman³

Affiliations

¹ Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
² Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA.
³ Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Electronic address: Isabel.Beerman@childrens.harvard.edu.

Abstract

The hematopoietic system undergoes many changes during aging, but the causes and molecular mechanisms behind these changes are not well understood. Wang et al. have recently implicated a circadian rhythm gene, Per2, as playing a role in the DNA damage response and in the expression of lymphoid genes in aged hematopoietic stem cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Aging*
Animals
Circadian Rhythm*
DNA Damage*
Gene Expression Regulation
Hematopoiesis*
Humans
Period Circadian Proteins / genetics

Substances

Per2 protein, mouse
Period Circadian Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding