Bifunctional αHER2/CD3 RNA-engineered CART-like human T cells specifically eliminate HER2(+) gastric cancer

Cell Res. 2016 Jul;26(7):850-3. doi: 10.1038/cr.2016.81. Epub 2016 Jun 24.

Authors

Feifei Luo^{1

2}, Jiawen Qian², Jiao Yang², Yuting Deng², Xiujuan Zheng², Jie Liu^{1

2}, Yiwei Chu^{1

2}

Affiliations

¹ Department of Digestive Diseases, Huashan Hospital and Department of Immunology of School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
² Biotherapy Research Center, Fudan University, Shanghai 200032, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
CD3 Complex / immunology*
Cell Line, Tumor
Female
Genetic Engineering
Humans
Immunotherapy, Adoptive*
Mice
RNA / genetics
Receptor, ErbB-2 / immunology*
Stomach Neoplasms / immunology*
Stomach Neoplasms / pathology
Stomach Neoplasms / therapy*
T-Lymphocytes / immunology*
T-Lymphocytes / metabolism
T-Lymphocytes / transplantation*
Xenograft Model Antitumor Assays

Substances

CD3 Complex
RNA
Receptor, ErbB-2