Labiopalatoschisis patients present functional and aesthetic alterations in the maxillomandibular area that often require prosthetic correction. Given the features of these malformations therapy and rehabilitation should be programmed as soon as possible after birth and the plastic surgeon should be informed of the factors that cause the malformations and influence the growth of such patients. The present paper briefly outlines the pathogenesis of L.P.S. and proposes a classification system for L.P.S. since both are considered essential for the understanding and assessment of its sequelae. The prosthetic-reconstructive problems in cases of cheilognathopalatoschisis subjected to orthodontic and surgical treatment are described since this is considered the most difficult form of rehabilitation the prosthesis is faced with.