1 Humanitas Research Hospital, Via Manzoni 113, Rozzano, MI 20089, Italy Milan Unit, Institute of Genetic and Biomedical Research, Via Manzoni 113, Rozzano, MI 20089, Italy Humanitas University, Via Manzoni 113, Rozzano, MI 20089, Italy leonardo.elia@humanitasresearch.it gianluigi.condorelli@hunimed.eu.