Targeting translesion synthesis to facilitate the eradication of ovarian cancer stem cells by platinum-based therapy

Amit Kumar Srivastava; Qi-En Wang

doi:10.1080/23723556.2015.1043482

Targeting translesion synthesis to facilitate the eradication of ovarian cancer stem cells by platinum-based therapy

Mol Cell Oncol. 2015 Jun 2;3(1):e1043482. doi: 10.1080/23723556.2015.1043482. eCollection 2016 Jan-Feb.

Authors

Amit Kumar Srivastava¹, Qi-En Wang¹

Affiliation

¹ Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Abstract

Understanding the mechanisms by which cancer stem cells (CSCs) survive chemotherapy is essential for the development of new therapies. Recently, we demonstrated that ovarian CSCs survive cisplatin treatment through enhanced expression of DNA polymerase η (Pol η). Identification of micro RNA-93 (miR-93) as the regulator of Pol η provides a novel target to improve the outcome of platinum-based therapy.

Keywords: Cancer stem cell; DNA repair; cisplatin resistance; translesion synthesis.