Regulation of hematopoietic progenitors by estrogens as a basis for new antileukemic strategies

Abel Sánchez-Aguilera; Simón Méndez-Ferrer

doi:10.1080/23723556.2015.1009728

Regulation of hematopoietic progenitors by estrogens as a basis for new antileukemic strategies

Mol Cell Oncol. 2015 Feb 3;3(1):e1009728. doi: 10.1080/23723556.2015.1009728. eCollection 2016 Jan.

Authors

Abel Sánchez-Aguilera¹, Simón Méndez-Ferrer¹

Affiliation

¹ Department of Cardiovascular Development and Repair; Centro Nacional de Investigaciones Cardiovasculares ; Madrid, Spain.

Abstract

We recently reported that estrogens regulate survival, proliferation, and self-renewal of hematopoietic stem cells and progenitors via estrogen receptor-α activation. Through its proapoptotic effect on malignant progenitors, tamoxifen treatment blocks the development of JAK2 (V617F) -induced myeloproliferative neoplasms in mice and sensitizes MLL-AF9-induced leukemias to chemotherapy, without detrimental effects on normal hematopoiesis.

Keywords: JAK2; MLL-AF9; acute myeloid leukemia; estrogen receptors; estrogens; hematopoietic progenitor cells; hematopoietic stem cells; myeloproliferative neoplasms; selective estrogen receptor modulators; tamoxifen.