Numerous studies have shown that normal cells often respond to the activation of oncogenes by undergoing reactive oxygen species-dependent induction of senescence. Here, we discuss our recent publication identifying protein tyrosine phosphatase PTP1B as an important redox-controlled checkpoint for senescence downstream of oncogenic RAS.
Keywords: PTP1B; argonaute; cancer; gene silencing; microRNAs; oncogene; p21; phosphatase; reactive oxygen species; senescence.