Abstract
Tailor-made compound formulation additives enable the testing of potential drugs with undesirable pharmacological profiles. A combinatorial approach using Raman microscopy as the readout method is presented to select peptide sequences from large one-bead-one-compound libraries. The resulting peptide-PEG conjugates solubilize potential prophylactic and therapeutic anti-Alzheimer compounds and can be used as specific additives not only for fluorescent but also for non-fluorescent compounds.
Keywords:
Alzheimer's disease; Tau protein; bioconjugates; combinatorial screening; precision polymers.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / drug therapy
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Drug Design
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Dynamic Light Scattering
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Humans
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Microscopy
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Molecular Conformation
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Molecular Dynamics Simulation
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Peptide Library
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Peptides / chemistry*
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Polyethylene Glycols / chemistry*
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Protein Aggregates / drug effects
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Protein Binding
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Small Molecule Libraries / chemistry*
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Small Molecule Libraries / pharmacology
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Small Molecule Libraries / therapeutic use
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Solubility
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Spectrum Analysis, Raman
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tau Proteins / chemistry
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tau Proteins / metabolism
Substances
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Peptide Library
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Peptides
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Protein Aggregates
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Small Molecule Libraries
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tau Proteins
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Polyethylene Glycols