Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates

J Am Chem Soc. 2016 Jun 29;138(25):7824-7. doi: 10.1021/jacs.6b03384. Epub 2016 Jun 16.

Abstract

Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive SN2-like oxidative addition of a nickel complex to the electrophilic substrate.

Publication types

  • Research Support, N.I.H., Extramural