Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

Guosheng Song; Yuyan Chen; Chao Liang; Xuan Yi; Jingjing Liu; Xiaoqi Sun; Sida Shen; Kai Yang; Zhuang Liu

doi:10.1002/adma.201602111

Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

Adv Mater. 2016 Sep;28(33):7143-8. doi: 10.1002/adma.201602111. Epub 2016 Jun 8.

Authors

Guosheng Song¹, Yuyan Chen¹, Chao Liang¹, Xuan Yi², Jingjing Liu¹, Xiaoqi Sun¹, Sida Shen¹, Kai Yang², Zhuang Liu¹

Affiliations

¹ Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
² School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, P. R. China.

PMID: 27275921
DOI: 10.1002/adma.201602111

Abstract

A novel type of bio-nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one-step method. Such bio-nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2 O2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia-induced radiotherapy resistance.

Keywords: bio-nanoreactors; enzyme delivery; hypoxia; radiotherapy; tantalum oxide.

MeSH terms

Animals
Catalase / administration & dosage*
Catalase / metabolism*
Mice
Nanoshells / administration & dosage*
Nanoshells / chemistry*
Neoplasms / metabolism*
Neoplasms / radiotherapy*
Oxygen / metabolism
Tumor Microenvironment

Substances

Catalase
Oxygen