Tapping out a mechanical code for T cell triggering

Michael L Dustin; Lance C Kam

doi:10.1083/jcb.201605072

Tapping out a mechanical code for T cell triggering

J Cell Biol. 2016 Jun 6;213(5):501-3. doi: 10.1083/jcb.201605072.

Authors

Michael L Dustin¹, Lance C Kam²

Affiliations

¹ Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskelatal Sciences, The University of Oxford, Oxford OX3 7FY, England, UK Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016 michael.dustin@kennedy.ox.ac.uk.
² Department of Biomedical Engineering, Columbia University, New York, NY 10027.

Abstract

Mechanical forces play increasingly recognized roles in T cell receptor (TCR) signal transduction. Hu and Butte (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511053) demonstrate that actin is required for T cells to generate forces at the TCR and that exogenous application of force can emulate these cytoskeletal forces and trigger T cell activation.

MeSH terms

Animals
Humans
Lymphocyte Activation
Microscopy, Atomic Force
Models, Biological
Receptors, Antigen, T-Cell
Signal Transduction
T-Lymphocytes / metabolism*

Substances

Receptors, Antigen, T-Cell