1 aDepartment of Infectious Diseases, Luigi Sacco University Hospital, Milan, Italy bUnit of Clinical Pharmacology, Luigi Sacco University Hospital, Milan, Italy cClinical Pharmacology Unit, CNR Institute of Neuroscience, Department Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Università di Milano, Milan Italy dScientific Institute IRCCS E.Medea, Bosisio Parini, Italy eSchool of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa.