Abstract
Three cadinane-type sesquiterpenoids, endoperoxide (1) and hydroperoxides (2, 3) together with three known sesquiterpenoids (4-6) were isolated from an Okinawan soft coral, Sinularia species. Structures of these isolates were elucidated by spectroscopic analyses (NMR, IR and MS) and molecular modeling. In addition, the isolates 1-3 as new compounds were examined for biological activities, resulting that they have antibacterial activity and weak cytotoxicity against HCT116 cells as well as anti-inflammatory effect on LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.
Keywords:
Anti-inflammatory; Cadinane; Cytotoxicity; HCT 116 cells; Sesquiterpenoid; Sinularia.
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Discovery / methods*
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Escherichia coli / drug effects
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HCT116 Cells
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Humans
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Inhibitory Concentration 50
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Macrophages / drug effects
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Macrophages / immunology
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Mice
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Molecular Structure
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Nitric Oxide / biosynthesis
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Polycyclic Sesquiterpenes
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Salmonella enterica / drug effects
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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cadinane
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Nitric Oxide