PGC1α drives a metabolic block on prostate cancer progression

Martina Wallace; Christian M Metallo

doi:10.1038/ncb3365

PGC1α drives a metabolic block on prostate cancer progression

Nat Cell Biol. 2016 May 27;18(6):589-90. doi: 10.1038/ncb3365.

Authors

Martina Wallace¹, Christian M Metallo^{1

2}

Affiliations

¹ Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.
² Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.

PMID: 27230528
DOI: 10.1038/ncb3365

Abstract

Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.

Publication types

Comment

MeSH terms

Animals
Cell Line, Tumor
Disease Progression*
ERRalpha Estrogen-Related Receptor
Gene Expression Regulation, Neoplastic
Humans
Male
Mice
Neoplasm Metastasis
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism*
Prostatic Neoplasms / genetics
Prostatic Neoplasms / pathology*
Receptors, Estrogen / metabolism
Transcriptome / genetics
Xenograft Model Antitumor Assays

Substances

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Receptors, Estrogen