Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China

Hua Yu; Fen Qu; Bin Shan; Bin Huang; Wei Jia; Cha Chen; Aiqing Li; Minhui Miao; Xin Zhang; Chunmei Bao; Yunmin Xu; Kalyan D Chavda; Yi-Wei Tang; Barry N Kreiswirth; Hong Du; Liang Chen

doi:10.1128/AAC.00440-16

Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China

Antimicrob Agents Chemother. 2016 Jul 22;60(8):5033-5. doi: 10.1128/AAC.00440-16. Print 2016 Aug.

Authors

Hua Yu¹, Fen Qu², Bin Shan³, Bin Huang⁴, Wei Jia⁵, Cha Chen⁶, Aiqing Li⁷, Minhui Miao⁷, Xin Zhang¹, Chunmei Bao², Yunmin Xu³, Kalyan D Chavda⁸, Yi-Wei Tang⁹, Barry N Kreiswirth⁸, Hong Du¹⁰, Liang Chen¹¹

Affiliations

¹ Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
² The Center of Clinical Diagnosis Laboratory, 302 Hospital of PLA, Beijing, China.
³ Department of Laboratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
⁴ Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
⁵ Center of Medical Laboratory, the General Hospital of Ningxia Medical University, Yinchuan, China.
⁶ Department of Laboratory Medicine, The Traditional Chinese Medical Hospital of Guangdong, Guangzhou, Guangdong, China.
⁷ Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
⁸ Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
⁹ Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
¹⁰ Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China hong_du@126.com Chen11@njms.rutgers.edu.
¹¹ Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA hong_du@126.com Chen11@njms.rutgers.edu.

Abstract

The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Carbapenems / pharmacology*
China
Chromosomes, Bacterial / genetics
Colistin / pharmacology*
Drug Resistance, Bacterial / genetics
Enterobacteriaceae / drug effects*
Enterobacteriaceae / genetics
Escherichia coli / drug effects
Escherichia coli / genetics
Hospitals
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents
Carbapenems
Colistin

Abstract

MeSH terms

Substances

Grants and funding