SnapShot: Microglia in Disease

Cell. 2016 May 19;165(5):1294-1294.e1. doi: 10.1016/j.cell.2016.05.036.

Abstract

The development and maintenance of the central nervous system is dependent upon regulated, homeostatic actions of microglia, which sculpt and refine neuronal circuitry. By contrast, dysregulation of microglia contributes to the pathology of neurodevelopmental disorders such as autism spectrum disorders; neurodegenerative disorders such as Alzheimer's disease; and schizophrenia and chronic neuropathic pain.

MeSH terms

  • Animals
  • Cognition
  • Humans
  • Microglia / metabolism*
  • Nervous System / cytology*
  • Nervous System Diseases / metabolism
  • Nervous System Diseases / pathology*
  • Nervous System Diseases / physiopathology