Synchronous pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma arising in the context of intraductal papillary neoplasms

Clin Imaging. 2016 Sep-Oct;40(5):897-901. doi: 10.1016/j.clinimag.2015.12.019. Epub 2016 Apr 23.

Abstract

Field cancerization theory provides rationale for the development of multiple pancreatic ductal and biliary lesions in a single patient through the development and accumulation of multiple genetic changes. Genetic alterations result in the development of precursor lesions including intraductal papillary mucinous neoplasms of the pancreas (IPMN), intraductal papillary neoplasm of the bile duct (IPN-B), and their malignant counterparts, pancreatic adenocarcinoma and cholangiocarcinoma. Although IPMN are frequently encountered, IPN-B are uncommon and the synchronous occurrence of both lesions is rare. We present a case of synchronous pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma with histopathologic evidence of underlying precursor lesions, IPMN-P and IPN-B.

Keywords: Cholangiocarcinoma; Intraductal papillary mucinous neoplasm of pancreas; Intraductal papillary neoplasm of the bile duct; Pancreatic adenocarcinoma; Synchronous.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / diagnosis*
  • Aged
  • Bile Duct Neoplasms / diagnosis*
  • Carcinoma, Pancreatic Ductal / diagnosis*
  • Cholangiocarcinoma / diagnosis*
  • Diagnosis, Differential
  • Endosonography / methods*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Male
  • Neoplasms, Multiple Primary / diagnosis*