Coala: an R framework for coalescent simulation

Bioinformatics. 2016 Jun 15;32(12):1903-4. doi: 10.1093/bioinformatics/btw098. Epub 2016 Feb 18.

Abstract

Simulation programs based on the coalescent efficiently generate genetic data according to a given model of evolution. We present coala, an R package for calling coalescent simulators with a unified syntax. It can execute simulations with several programs, calculate additional summary statistics and combine multiple simulations to create biologically more realistic data.

Availability and implementation: The package is publicly available on CRAN and on https://github.com/statgenlmu/coala under the conditions of the MIT license.

Contact: metzler@bio.lmu.de.

MeSH terms

  • Computational Biology / methods*
  • Computer Simulation
  • Evolution, Molecular*
  • Genetics, Population
  • Models, Genetic*
  • Software*