External Magnetic Field-Induced Targeted Delivery of Highly Sensitive Iron Oxide Nanocubes for MRI of Myocardial Infarction

Bingbing Hu; Mu Zeng; Jingli Chen; Zhenzhong Zhang; Xiaoning Zhang; Zhanming Fan; Xin Zhang

doi:10.1002/smll.201600263

External Magnetic Field-Induced Targeted Delivery of Highly Sensitive Iron Oxide Nanocubes for MRI of Myocardial Infarction

Small. 2016 Sep;12(34):4707-12. doi: 10.1002/smll.201600263. Epub 2016 May 4.

Authors

Bingbing Hu¹, Mu Zeng², Jingli Chen^{1

3}, Zhenzhong Zhang³, Xiaoning Zhang⁴, Zhanming Fan⁵, Xin Zhang⁶

Affiliations

¹ National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
² Department of Radiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, 100029, P. R. China.
³ School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, P. R. China.
⁴ Collaborative Innovation Center for Biotherapy, School of Medicine, Tsinghua University, Beijing, 100084, P. R. China.
⁵ Department of Radiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, 100029, P. R. China. fanzm120@126.com.
⁶ National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China. xzhang@ipe.ac.cn.

PMID: 27147555
DOI: 10.1002/smll.201600263

Abstract

Magnetic field responsive nanocubes (MFRFs) are synthesized as nanoplatforms for external magnetic field-induced selective targeting of macrophages in the infarcted tissue and magnetic resonance imaging (MRI) monitoring. MFRFs have uniform size, favorable colloidal stability, and high magnetic properties. Under the influence of external magnetic field, MFRFs perform qualitative and quantitative MRI of myocardial infarction.

Keywords: external magnetic fields; iron oxide nanocubes; magnetic field responsive; magnetic resonance imaging; myocardial infarction.

MeSH terms

Animals
Cell Death / drug effects
Ferric Compounds / pharmacology*
Magnetic Fields*
Magnetic Resonance Imaging*
Mice
Myocardial Infarction / diagnosis*
Myocardial Infarction / pathology
Myocardium / pathology
Nanoparticles / chemistry*
Nanoparticles / toxicity
RAW 264.7 Cells
Rats
Spectroscopy, Fourier Transform Infrared

Substances

Ferric Compounds
ferric oxide