Abstract
The Fc-fusion mimetic RpR 2[combining low line] was prepared by disulfide bridging conjugation using PEG in the place of the Fc. RpR 2[combining low line] displayed higher affinity for VEGF than aflibercept. This is caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.
MeSH terms
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Disulfides / chemistry
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Humans
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Immunoglobulin Fab Fragments / chemistry
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Immunoglobulin Fab Fragments / immunology
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Immunoglobulin G / immunology
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Molecular Weight
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Polyethylene Glycols / chemistry
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Protein Binding / immunology
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Protein Multimerization
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Receptors, Vascular Endothelial Growth Factor / chemistry*
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Receptors, Vascular Endothelial Growth Factor / immunology*
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Recombinant Fusion Proteins / chemistry*
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Recombinant Fusion Proteins / immunology*
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Vascular Endothelial Growth Factor A / immunology*
Substances
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Disulfides
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Immunoglobulin Fab Fragments
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Immunoglobulin G
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Recombinant Fusion Proteins
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Vascular Endothelial Growth Factor A
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aflibercept
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Polyethylene Glycols
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Receptors, Vascular Endothelial Growth Factor