Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

ACS Appl Mater Interfaces. 2016 May 18;8(19):12039-47. doi: 10.1021/acsami.6b02721. Epub 2016 May 5.

Abstract

Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.

Keywords: lysosome-targeting; near-infrared absorption; photoacoustic imaging; photodynamic therapy; theranostic nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • A549 Cells
  • Animals
  • Boron Compounds* / chemistry
  • Boron Compounds* / pharmacology
  • Drug Delivery Systems
  • Humans
  • Lysosomes / metabolism*
  • Mice
  • Mice, Nude
  • Nanoparticles* / chemistry
  • Nanoparticles* / therapeutic use
  • Neoplasms / diagnostic imaging*
  • Neoplasms / drug therapy*
  • Photoacoustic Techniques*
  • Photochemotherapy*
  • Xenograft Model Antitumor Assays

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Boron Compounds