Convenient synthesis of phosphonohydrazines from arylamines

Tetrahedron Lett. 2016 Apr 11;57(19):2097-2099. doi: 10.1016/j.tetlet.2016.03.111.

Abstract

Phosphonohydrazines were prepared in good yield from corresponding arylamines by a one-pot reaction through diazotization with an organic nitrite and treatment with a trialkyl phosphite. The trialkyl phosphite is postulated to function as a nucleophile as well as a reducing agent.

Keywords: alkyl nitrite; arylamine; diazo compounds; phosphonohydrazine; reduction; trialkyl phosphite.