Engineering Models to Scale

Aaron J Dy; James J Collins

doi:10.1016/j.cell.2016.04.017

Engineering Models to Scale

Cell. 2016 Apr 21;165(3):516-7. doi: 10.1016/j.cell.2016.04.017.

Authors

Aaron J Dy¹, James J Collins²

Affiliations

¹ Institute for Medical Engineering and Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
² Institute for Medical Engineering and Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: jimjc@mit.edu.

PMID: 27104972
DOI: 10.1016/j.cell.2016.04.017

Abstract

Developing organisms can regulate and scale patterns to achieve consistent proportions despite immense changes in size. In this issue, Cao et al. build a model system, using engineered E. coli, to understand how regulatory dynamics can produce pattern scaling without the need for a morphogen gradient.

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MeSH terms

Body Patterning*
Escherichia coli
Gene Expression Regulation, Developmental*
Models, Biological