Synthesis and Antiviral Bioassay of New Diphenyl Ether-based Compounds

Chem Biol Drug Des. 2016 Oct;88(4):511-8. doi: 10.1111/cbdd.12775. Epub 2016 May 27.

Abstract

A set of diphenyl ether derivatives bearing different heterocycles were synthesized from 4-phenoxybenzohydrazide 1 in good yield. Synthesized compounds were screened against a broad panel of viruses in different cell cultures and some of the synthesized compounds showed promising antiviral properties.

Keywords: antiviral; chemical biology; diphenyl ethers; drug discovery; heterocycles.

MeSH terms

  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Biological Assay
  • Biphenyl Compounds / chemical synthesis*
  • Biphenyl Compounds / chemistry
  • Biphenyl Compounds / pharmacology*
  • Cells, Cultured
  • Drug Evaluation, Preclinical
  • Ether / chemical synthesis*
  • Ether / chemistry
  • Ether / pharmacology*
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology
  • Pyridines / chemistry
  • Pyridines / pharmacology
  • Viruses / drug effects*

Substances

  • 3-(5-((6-amino-1H-pyrazolo(3,4-b)pyridine-3-yl)methoxy)-2-chlorophenoxy)-5-chlorobenzonitrile
  • Antiviral Agents
  • Biphenyl Compounds
  • Pyrazoles
  • Pyridines
  • Ether