Novel t(1;3)(q21,p21) translocation in a basal cell adenocarcinoma of the parotid gland: potential association with tumorigenesis

Karan Saluja; Pulivarthi H Rao; Jeffery N Myers; Adel K El-Naggar

doi:10.1016/j.humpath.2016.03.019

Novel t(1;3)(q21,p21) translocation in a basal cell adenocarcinoma of the parotid gland: potential association with tumorigenesis

Hum Pathol. 2016 Aug:54:189-92. doi: 10.1016/j.humpath.2016.03.019. Epub 2016 Apr 13.

Authors

Karan Saluja¹, Pulivarthi H Rao², Jeffery N Myers³, Adel K El-Naggar⁴

Affiliations

¹ Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
² Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
³ Department of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
⁴ Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030. Electronic address: anaggar@mdanderson.org.

PMID: 27085552
DOI: 10.1016/j.humpath.2016.03.019

Abstract

We report a rare translocation involving chromosomes 1q23 and 3p21 regions in a basaloid salivary carcinoma. Our case together with a previously reported instance of translocation involving chromosome 1q 21-24 region defines a specific chromosomal segment that may house a gene associated with the development of a subset of basaloid salivary tumors.

Keywords: Adenocarcinoma; Adenoma; Basal cell; Salivary tumor; Translocation.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / genetics*
Adenocarcinoma / pathology
Adenocarcinoma / surgery
Biopsy
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 3*
Female
Genetic Predisposition to Disease
Humans
Karyotyping
Middle Aged
Parotid Neoplasms / genetics*
Parotid Neoplasms / pathology
Parotid Neoplasms / surgery
Phenotype
Translocation, Genetic*