Terpenoids with anti-inflammatory activity from Abies chensiensis

Qian-Qian Zhao; Shu-Fang Wang; Ya Li; Qiu-Yan Song; Kun Gao

doi:10.1016/j.fitote.2016.04.002

Terpenoids with anti-inflammatory activity from Abies chensiensis

Fitoterapia. 2016 Jun:111:87-94. doi: 10.1016/j.fitote.2016.04.002. Epub 2016 Apr 11.

Authors

Qian-Qian Zhao¹, Shu-Fang Wang², Ya Li¹, Qiu-Yan Song¹, Kun Gao³

Affiliations

¹ State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
² Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, PR China.
³ State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China. Electronic address: npchem@lzu.edu.cn.

PMID: 27080759
DOI: 10.1016/j.fitote.2016.04.002

Abstract

The phytochemical investigation of Abies chensiensis led to the isolation and identification of nine new compounds including eight triterpenoids (1-8) and a new abietane-type diterpene (9), along with three known compounds (10-12). The absolute configuration of 9 was assigned by X-ray diffraction analysis. Compounds 1-11 were evaluated for the anti-inflammatory activity. Among the tested compounds, 1, 2, 5 and 6 exhibited potent inhibitory activity with IC50 values of 15.97, 18.73, 20.18 and 10.97μM, respectively.

Keywords: Abies chensiensis; Anti-inflammatory activity; Terpenoids.

MeSH terms

Abies / chemistry*
Animals
Anti-Inflammatory Agents / chemistry*
Anti-Inflammatory Agents / isolation & purification
Crystallography, X-Ray
Diterpenes / chemistry
Inhibitory Concentration 50
Mice
Molecular Structure
Nitric Oxide / metabolism
Plant Components, Aerial / chemistry
Plant Extracts / chemistry
RAW 264.7 Cells
Terpenes / chemistry*
Terpenes / isolation & purification
Triterpenes / chemistry
Triterpenes / isolation & purification

Substances

Anti-Inflammatory Agents
Diterpenes
Plant Extracts
Terpenes
Triterpenes
Nitric Oxide