High-Sensitivity Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Prediction of Outcome in Congenital Diaphragmatic Hernia: Results from a Multicenter, Randomized Controlled Trial

Kitty G Snoek; Ulrike S Kraemer; Chantal A Ten Kate; Anne Greenough; Arno van Heijst; Irma Capolupo; Thomas Schaible; Joost van Rosmalen; René M Wijnen; Irwin K M Reiss; Dick Tibboel

doi:10.1016/j.jpeds.2016.03.026

High-Sensitivity Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Prediction of Outcome in Congenital Diaphragmatic Hernia: Results from a Multicenter, Randomized Controlled Trial

J Pediatr. 2016 Jun:173:245-249.e4. doi: 10.1016/j.jpeds.2016.03.026. Epub 2016 Apr 11.

Authors

Affiliations

¹ Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
² Division of Asthma, Allergy and Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, Denmark Hill, London, United Kingdom.
³ Division of Neonatology, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
⁴ Department of Medical and Surgical Neonatology, Bambino Gesu Children's Hospital, Rome, Italy.
⁵ Department of Pediatrics, Universitätsmedizin Mannheim, Mannheim, Germany.
⁶ Department of Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
⁷ Department of Neonatology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.

PMID: 27079964
DOI: 10.1016/j.jpeds.2016.03.026

Abstract

Biomarkers may be helpful in prediction of outcomes of infants with congenital diaphragmatic hernia. The predictive value of high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide was investigated in 128 infants with congenital diaphragmatic hernia. After correction for multiple testing, those biomarkers did not predict severe pulmonary hypertension, death, need of extracorporeal membrane oxygenation, or bronchopulmonary dysplasia.

Trial registration: Netherlands Trial Registry: 1310.

Keywords: Biomarkers; pulmonary hypertension.

Publication types

Multicenter Study
Randomized Controlled Trial

MeSH terms

Biomarkers / blood
Bronchopulmonary Dysplasia / epidemiology
Extracorporeal Membrane Oxygenation / statistics & numerical data
Female
Hernias, Diaphragmatic, Congenital / mortality*
Hernias, Diaphragmatic, Congenital / surgery
Humans
Hypertension, Pulmonary / epidemiology
Infant, Newborn
Male
Natriuretic Peptide, Brain / blood*
Netherlands / epidemiology
Prognosis
Prospective Studies
Severity of Illness Index
Troponin T / blood*

Substances

Biomarkers
Troponin T
Natriuretic Peptide, Brain