Focus Issue: New insights in GPCR to G protein signaling

Sci Signal. 2016 Apr 12;9(423):eg6. doi: 10.1126/scisignal.aaf7642.

Abstract

This Focus Issue highlights new discoveries at the level of the receptor, the α subunit, and the βγ subunit and spans research in yeast on polarized growth and G protein-coupled receptor (GPCR) trafficking, in mice on an orphan GPCR with constitutive activity, and a disease-causing mutation in an α subunit that results in inappropriate GPCR-G protein coupling.

Publication types

  • Editorial
  • Introductory Journal Article

MeSH terms

  • Animals
  • Ear / abnormalities*
  • Ear Diseases / genetics*
  • Ear Diseases / metabolism
  • GTP-Binding Proteins / genetics*
  • GTP-Binding Proteins / metabolism
  • Humans
  • Mutation*
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Receptors, G-Protein-Coupled / genetics*
  • Receptors, G-Protein-Coupled / metabolism
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction / genetics*

Substances

  • Protein Subunits
  • Receptors, G-Protein-Coupled
  • Saccharomyces cerevisiae Proteins
  • GTP-Binding Proteins

Supplementary concepts

  • Auriculo-condylar syndrome