Recombination among GB virus C (GBV-C) isolates in the United States

J Gen Virol. 2016 Jul;97(7):1537-1544. doi: 10.1099/jgv.0.000477. Epub 2016 Apr 11.

Abstract

GB virus C (GBV-C) is a non-pathogenic flavivirus that may play a role in modulating HIV disease. Multiple genotypes of GBV-C that have been identified to date that may differentially regulate HIV; however, the number of complete GBV-C sequences published to date is very limited. We sequenced full-length GBV-C genomes from four individuals with HIV/HCV co-infection in the United States. Intergenotypic recombination was evident in two of these individuals. Evaluation of additional full-length GBV-C genomes would facilitate the creation of full-length, replication-competent molecular clones of GBV-C to evaluate the phenotypic diversity of GBV-C genotypes and provide important molecular data on this understudied virus.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Coinfection
  • Flaviviridae Infections / virology
  • GB virus C / genetics*
  • GB virus C / isolation & purification*
  • Genome, Viral / genetics*
  • Humans
  • Phylogeny
  • Prospective Studies
  • RNA, Viral / genetics
  • Recombination, Genetic / genetics*
  • Sequence Analysis, RNA
  • United States

Substances

  • RNA, Viral