Proactive for invasion: Reuse of matrix metalloproteinase for structural memory

Erika Gucciardo; Mohammad Mobashir; Kaisa Lehti

doi:10.1083/jcb.201603066

Proactive for invasion: Reuse of matrix metalloproteinase for structural memory

J Cell Biol. 2016 Apr 11;213(1):11-3. doi: 10.1083/jcb.201603066.

Authors

Erika Gucciardo¹, Mohammad Mobashir², Kaisa Lehti³

Affiliations

¹ Research Programs Unit, Genome-Scale Biology and Haartman Institute, University of Helsinki, Helsinki University Hospital and Finnish Cancer Institute, Helsinki FI-00014, Finland.
² Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Stockholm SE-17165, Sweden.
³ Research Programs Unit, Genome-Scale Biology and Haartman Institute, University of Helsinki, Helsinki University Hospital and Finnish Cancer Institute, Helsinki FI-00014, Finland Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Stockholm SE-17165, Sweden kaisa.lehti@ki.se.

Abstract

Migratory cells translocate membrane type-1 matrix metalloproteinase (MT1-MMP) to podosomes or invadosomes to break extracellular matrix barriers. In this issue, El Azzouzi et al. (2016.J. Cell. Biol.http://dx.doi.org/10.1083/jcb.201510043) describe an unexpected function for the MT1-MMP cytoplasmic domain in imprinting spatial memory for podosome reformation via assembly in membrane islets.

MeSH terms

Cell Movement / physiology
Cytoplasm / metabolism
Extracellular Matrix / metabolism
Humans
Matrix Metalloproteinase 14 / metabolism
Matrix Metalloproteinases / metabolism*
Podosomes / metabolism
Protein Structure, Tertiary / physiology

Substances

Matrix Metalloproteinases
MMP14 protein, human
Matrix Metalloproteinase 14