Disruption of evasive immune cell microenvironment in tumors reflects immunity induced by radiation therapy

Alexander Filatenkov; Jeanette Baker; Samuel Strober

doi:10.1080/2162402X.2015.1072673

Disruption of evasive immune cell microenvironment in tumors reflects immunity induced by radiation therapy

Oncoimmunology. 2016 Feb 26;5(2):e1072673. doi: 10.1080/2162402X.2015.1072673. eCollection 2016 Feb.

Authors

Alexander Filatenkov¹, Jeanette Baker², Samuel Strober¹

Affiliations

¹ Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine , Stanford, CA, USA.
² Division of Blood and Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine , Stanford, CA, USA.

Abstract

Radiation administered to murine colon tumors induced durable remissions that were dependent on CD4⁺ and CD8⁺ T cell immunity, and antigen cross priming CD8⁺ dendritic cells (DCs). Remissions were associated with marked reductions in the infiltration of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and Treg cells, and a marked increase in CD8⁺ T cells.

Keywords: tumor immunity; CD8 T cells; colon tumors; radiation therapy; tumor microenvironment.

Publication types

Research Support, N.I.H., Extramural

Grants and funding

R01 CA163441/CA/NCI NIH HHS/United States