Trace metal levels in serum and urine of a population in southern Brazil

G H O Rocha; C Steinbach; J R Munhoz; M A O Madia; J K Faria; D Hoeltgebaum; F Barbosa Jr; B L Batista; V C O Souza; S B Nerilo; E Bando; S A G Mossini; P Nishiyama

doi:10.1016/j.jtemb.2015.12.005

Trace metal levels in serum and urine of a population in southern Brazil

J Trace Elem Med Biol. 2016 May:35:61-5. doi: 10.1016/j.jtemb.2015.12.005. Epub 2015 Dec 23.

Authors

G H O Rocha¹, C Steinbach¹, J R Munhoz¹, M A O Madia¹, J K Faria¹, D Hoeltgebaum¹, F Barbosa Jr², B L Batista³, V C O Souza², S B Nerilo⁴, E Bando⁴, S A G Mossini⁴, P Nishiyama⁵

Affiliations

¹ Laboratory of Toxicology, Course of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil.
² Laboratory of Metal Toxicology and Essentiality, Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
³ Laboratory of Metal Toxicology and Essentiality, Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Natural and Human Sciences Centre, Federal University of the ABC, Santo André, São Paulo, Brazil.
⁴ Laboratory of Toxicology, Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil.
⁵ Laboratory of Toxicology, Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil. Electronic address: pnishiyama@uem.br.

PMID: 27049127
DOI: 10.1016/j.jtemb.2015.12.005

Abstract

This study aimed to evaluate serum and urine concentrations of several trace metals of a non-directly exposed population in southern Brazil and establish reference values. Serum and urine samples were obtained from 240 volunteers (175 males and 65 females, age ranging from 18 to 74 years old). Levels of arsenic, chromium, cobalt, copper, lead, nickel, manganese and zinc were determined by means of dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS). Comparison between genders resulted in no significant difference for all metals but serum copper, as concentrations are higher in females than males. For most metals assessed, a negative correlation between serum concentrations and age was found, but no significant correlation was found between urine concentrations and age.

Keywords: Dynamic reaction cell inductively coupled plasma mass spectrometry; Fluid analyses; Non-occupational exposure; Population studies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Brazil
Female
Humans
Male
Middle Aged
Reference Standards
Trace Elements / blood*
Trace Elements / urine*
Young Adult

Substances

Trace Elements