PyMIF enhances the inflammatory response in a rodent model by stimulating CD11b(+) Ly6C(+) cells accumulation in spleen

Parasite Immunol. 2016 Jun;38(6):377-83. doi: 10.1111/pim.12320.

Abstract

Macrophage migration inhibitory factor (PMIF) expressed by Plasmodium parasites has been proved to be similar to the mammalian MIF in both structure and biological activity and is a critical upstream regulator in antimalaria innate immunity. In this work, using a genetically modified (MIF-KO) strain of highly lethal rodent Plasmodium yoelii 17XL (Py17XL), we found that PyMIF could increase the secretion of pro-inflammatory factors by eliciting the CD11b(+) Ly6C(+) cells accumulated in the spleen of infected mouse. In addition, the chemotactic effect of PyMIF was demonstrated to associate with cell receptors CXCR2, CXCR4 and the cell surface markers ICAM-1, LFA-4.

Keywords: immunological terms; malaria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Ly / immunology*
  • CD11b Antigen / immunology*
  • Disease Models, Animal
  • Female
  • Humans
  • Immunity, Innate
  • Macrophage Migration-Inhibitory Factors / immunology*
  • Malaria / immunology*
  • Malaria / parasitology
  • Mice
  • Mice, Inbred BALB C
  • Plasmodium yoelii / immunology*
  • Plasmodium yoelii / physiology
  • Protozoan Proteins / immunology*
  • Receptors, CXCR4 / immunology
  • Receptors, Interleukin-8B / immunology
  • Spleen / immunology*
  • Spleen / parasitology

Substances

  • Antigens, Ly
  • CD11b Antigen
  • CXCR4 protein, mouse
  • Ly-6C antigen, mouse
  • Macrophage Migration-Inhibitory Factors
  • Protozoan Proteins
  • Receptors, CXCR4
  • Receptors, Interleukin-8B