Rational design of multifunctional small-molecule prodrugs for simultaneous suppression of cancer cell growth and metastasis in vitro and in vivo

Haiyang Xie; Xiao Xu; Jianmei Chen; Lingling Li; Jianguo Wang; Tao Fang; Lin Zhou; Hangxiang Wang; Shusen Zheng

doi:10.1039/c5cc10367c

Rational design of multifunctional small-molecule prodrugs for simultaneous suppression of cancer cell growth and metastasis in vitro and in vivo

Chem Commun (Camb). 2016 Apr 25;52(32):5601-4. doi: 10.1039/c5cc10367c.

Authors

Haiyang Xie¹, Xiao Xu¹, Jianmei Chen¹, Lingling Li¹, Jianguo Wang¹, Tao Fang², Lin Zhou¹, Hangxiang Wang¹, Shusen Zheng¹

Affiliations

¹ The First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China. wanghx@zju.edu.cn.
² Jinhua People's Hospital, Jinhua, Zhejiang Province 321000, P. R. China.

PMID: 27027105
DOI: 10.1039/c5cc10367c

Abstract

We present a design concept for multifunctional prodrugs that simultaneously induce apoptosis and suppress cancer cell metastasis in vitro and in vivo. These "all-in-one" prodrug constructs possess therapeutic potential as novel "integrative" platforms for metastatic cancer treatment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Cell Line
Cell Proliferation*
Humans
In Vitro Techniques
Neoplasm Metastasis*
Neoplasms / pathology*
Prodrugs / chemical synthesis*
Prodrugs / pharmacology*

Substances

Antineoplastic Agents
Prodrugs