Basosquamous papilloma. A benign epithelial skin tumor with multiple cytogenetic clones

F Mertens; S Heim; Y S Jin; B Johansson; N Mandahl; A Biörklund; J Wennerberg; N Jonsson; F Mitelman

doi:10.1016/0165-4608(89)90054-x

Basosquamous papilloma. A benign epithelial skin tumor with multiple cytogenetic clones

Cancer Genet Cytogenet. 1989 Feb;37(2):235-9. doi: 10.1016/0165-4608(89)90054-x.

Authors

F Mertens¹, S Heim, Y S Jin, B Johansson, N Mandahl, A Biörklund, J Wennerberg, N Jonsson, F Mitelman

Affiliation

¹ Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

PMID: 2702623
DOI: 10.1016/0165-4608(89)90054-x

Abstract

Cytogenetic analysis of short-term cultures from a basosquamous papilloma revealed the following mosaic karyotype: 46,XX,t(2;5)(q31;q31),t(8;15)(p21;q21)/46,XX,t(7;17)(p13;p13)/47,XX, t(3;20)(q12;p13),+7/46,XX,t(1:12)(p12;q13). The finding of four abnormal, cytogenetically unrelated clones suggests a multicellular origin of this benign skin tumor. None of the structural rearrangements encountered have previously been associated with neoplasia.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Chromosome Aberrations*
Female
Gene Rearrangement
Humans
Papilloma / genetics*
Skin Neoplasms / genetics*