1 Oxford University Hospitals NHS Trust , Oxford , UK.
2 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; The Oxford-UCL Centre for the Advancement of Sustainable Medical Innovation (CASMI), The University of Oxford, Oxford, UK.
3 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; The Oxford-UCL Centre for the Advancement of Sustainable Medical Innovation (CASMI), The University of Oxford, Oxford, UK; Centre for Behavioural Medicine, UCL School of Pharmacy, University College London, London, UK; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA; USCF-Stanford Center of Excellence in Regulatory Science and Innovation (CERSI), USA.