Abstract
The methanolic extract of the Tanacetum gracile afforded the isolation of new sesquiterpene lactone, named gracilone (1) along with four known compounds as 14α-taraxeran-3-one (2), 14α-taraxeran-3-ol (3), apigenin (4) and β-sitosterol (5). The structure of compound 1 was elucidated on the basis of 1D, 2D NMR and MS spectroscopic analysis. Antimicrobial, antioxidant and anticancer activities of all compounds were evaluated, from which gracilone (1) showed a moderate antibacterial activity, while apigenin (4) showed comparatively more antibacterial activity against both gram-positive and gram-negative tested strains.
Keywords:
Tanacetum gracile; antibacterial; anticancer activity; antioxidant; gracilone.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Cell Line, Tumor
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Drug Evaluation, Preclinical / methods
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Humans
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Inhibitory Concentration 50
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Sitosterols / isolation & purification
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Sitosterols / pharmacology
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Tanacetum / chemistry*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Lactones
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Sesquiterpenes
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Sitosterols
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gracilone
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gamma-sitosterol